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For most drugs, metabolism plays an important role in their clearance. For orally administered drugs, bioavailability is significantly affected by first-pass metabolism in the liver. Therefore, the metabolic stability of a drug can have very important pharmacokinetic and clinical significance in vivo.

Liver microsomes are the most popular and widely used in vitro systems to evaluate metabolic stability. Drumetix provides metabolic stability assay in human, monkey, dog, rat, and mouse liver microsomes, using LC-MS/MS to measure parent compound disappearance after incubation. Either percent remaining (comparing 0 and 1 hr incubation) or in vitro elimination half-life (multiple time points) can be determined.

Propranolol is used as a control in our metabolic stability assay.