Serving Your Needs in Drug Metabolism and Pharmacokinetics
HomeCapabilitiesIn Vitro DMPK (ADME)Small Molecule BiomarkersBioanalyticalAnalytical ServiceStability TestingBiological ServicesCareerContact
Bioanalytical CRO Service Provider
DMPK Assay CRO Service Provider
ADME CRO Assay Service Provider
Biomarker Analysis CRO Service Provider
CMC Analytical Stability Testing CRO Service Provider

Biomarkers are becoming more and more important in disease diagnosis and drug efficacy and safety evaluation. They can help identify early pathological processes, leading to early therapy. Biomarkers allowing earlier and more robust toxicity and therapeutic effectiveness assessment may significantly increase the success rate of drug development programs. Compared to protein biomarkers, small molecule biomarkers (or metabolic biomarkers) are less species dependent. Therefore, data from animal studies with small molecule biomarkers should be translatable to the human condition. Methodologies and technologies recently developed in the fields of metabolomics and metabonomics are accelerating the discovery of new small molecule biomarkers.

We provides LC-MS/MS based highly selective, sensitive, and accurate analysis of small molecule biomarkers:

  • Desmosine and isodesmosine
  • Neurotransmitters
  • All-trans retinoic acid (atRA or tretinoin) and 4-hydroxy all-trans retinoic acid
  • Creatinine
  • Biological fluid and tissue samples
  • Method development for any small molecule biomarker upon request.