Protein Characterization, Protein Quantification, Monoclonal Antibody

Antibody Drug Conjugate, Fusion Protein, Protein Biomarker

Biological Mass Spectrometry, Protein Bioanalysis, Protein Quantitative LC/MS

Since the introduction of recombinant human insulin to the pharmaceutical market in 1982, these past 30 years have witnessed a landscape change in the pharmaceutical industry in moving towards biotherapeutics. In 2017, seven out of the ten top selling pharmaceuticals were biopharmaceuticals. The majority of the biopharmaceuticals are monoclonal antibodies. Other protein-based drug modalities include therapeutic enzymes, fusion proteins, antibody drug conjugates, etc. In comparison with small molecule drugs, biopharmaceuticals possess tremendous structural complexity. The structural characterization of biotherapeutics is crucial to ensure consistent drug efficacy and safety.

At Drumetix Laboratories, our protein characterization services are hinged on LC/MS techniques. The service areas we offer include the following:

• Intact molecule mass measurement
• Subunit mass measurement, if applicable
• Protein sequence confirmation
• Post-translational modification identification
• Drug antibody ratio (DAR) determination for antibody drug conjugates (ADC)